Pharmacology & Metabolism of JWH-018

Pharmacology studies indicate JWH-018 has Δ9-THC-like activity affecting cardiovascular and central nervous systems and causing psychoactive effects such as decreased activity and body temperature, analgesia and catalepsy, related to its binding to central cannabinoid receptor, CB1, and peripheral cannabinoid receptor, CB2 (6). The reported biding affinity of JWH-018 for CB1 and CB2 receptors is 9.00±5.00 […]